Epidemiology

  • Demographics and outcomes: A study examining 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020, showed:[1]

    • Median age: 47 years

    • Gender: 41.9% of the patients were female. 

    • Admission to an intensive care unit (ICU): 5.0%

    • Use of mechanical ventilation: 2.3%

    • Death: 1.4%

  • Risk factors: A study of 191 admitted patients in Wuhan showed the following:[2]

    • 48% of patients had a comorbidity

      • 30% had hypertension 

      • 19% had diabetes 

      • 8% had coronary heart disease 

    • Risk of in-hospital death was associated with: 

      • Older age: odds ratio 1.10, 95% CI 1.03–1.17, per year increase; p=0·0043

      • Higher Sequential Organ Failure Assessment (SOFA) score (5.65, 2.61–12.23; p<0·0001)

      • D-dimer greater than 1 μg/mL (18.42, 2.64–128.55; p=0·0033) on admission 

References

1.      Guan, W.-J. et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N. Engl. J. Med. (2020). doi:10.1056/NEJMoa2002032

2.      Zhou, F. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan , China : a retrospective cohort study. Lancet 6736, 1–9 (2020).

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